By Errol C Friedberg
With a Foreword by means of Sydney Brenner (Nobel laureate in body structure or medication, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from delivery, in 1926, to the current, with designated emphasis on his huge, immense medical contributions, together with being the 1st to enhance know-how that resulted in gene cloning technology. In 1980, Berg obtained a Nobel Prize in chemistry for this work.
In addition to his contributions within the study laboratory, Berg orchestrated and oversaw a old assembly at Asilomar, California that situated on a threatening controversy surrounding the belief by means of many of the destructive strength of recombinant DNA expertise. This assembly did a lot to stop this controversy and to install position the law of recombinant DNA paintings, therefore placing fears to rest.
The recombinant DNA controversy used to be a historical consequence of the invention of gene cloning. significantly, it represented a paramount instance of medical foresight and due diligence through the medical neighborhood, instead of via regulatory entities within the usa and plenty of different international locations. the final word recognition of gene/DNA cloning ended in a brand new period of contemporary biology that flourishes to the present.
This booklet is aimed basically at scientists and people in education. The publication strives to easily offer details for the final reader, yet isn't really particularly adapted for a common examining audience.
While many books conceal the recombinant DNA controversy, none have satisfactorily addressed this old interval and are usually contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written via non-scientists. This biography of Paul Berg offers entry to varied archived letters and files at Stanford collage no longer formerly addressed, and to the chronology of occasions as recalled and documented through him, in addition to different key personalities, a lot of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and global warfare II
- Western Reserve University
- Part II:
- Washington college, St. Louis
- Discovering move RNA
- Stanford college — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a massive Breakthrough
- EcoRI limit Endonuclease — a tremendous Breakthrough
- “Coincidence is the observe We Use once we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An historical assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon examine Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a unique element of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage matters — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in lifestyles sciences, medication and chemistry and lay public.
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Extra resources for A Biography of Paul Berg:The Recombinant DNA Controversy Revisited
A Biography of Paul Berg:The Recombinant DNA Controversy Revisited by Errol C Friedberg